La Crosse Regional Airport (LSE/KLSE) is a small commercial service airport located in La Crosse, Wisconsin, serving the Coulee Region along the upper Mississippi River. It provides scheduled passenger service connecting the area to major hub airports, complementing the region's role as a medical, educational, and tourism center. The airport is owned and operated by the City of La Crosse and handles general aviation in addition to commercial flights. Despite its modest size, it plays an important role in the regional transportation network of western Wisconsin and southeastern Minnesota. The facility has undergone various infrastructure improvements over the years to maintain safety standards and accommodate modern regional jet aircraft used by its airline partners.