St. Mathews Airport is a small general aviation facility located in St. Mathews, South Carolina, United States. It operates under the identifier 99SC and does not hold an IATA code, reflecting its status as a private or local-use airfield rather than a commercial passenger airport. The airport primarily serves private pilots, agricultural aviation, and local flight operations in Calhoun County. Like many rural general aviation airports in South Carolina, it plays a supporting role in regional connectivity and agricultural services.