Santa Barbara Airlines was a Venezuelan regional and domestic carrier that operated scheduled passenger services across Venezuela and to select international destinations in South America and the Caribbean. The airline was named after the patron saint of the Venezuelan plains region and served as an important link between smaller Venezuelan cities and the capital, Caracas. The airline faced significant operational and financial challenges typical of Venezuelan carriers during the country's prolonged economic crisis. Santa Barbara Airlines ultimately ceased operations, a fate shared by several other Venezuelan airlines amid fuel shortages, currency controls, and broader economic instability in Venezuela during the 2010s.